"It is time," said Rezia.
The word "time" split its husk; poured its riches over him; and from his lips fell like shells, like shavings from a plane, without his making them, hard, white, imperishable words, and flew to attach themselves to their places in an ode to Time; an immortal ode to Time. (4.47-48)
Rezia’s efforts to get Septimus to the doctor are kind of futile. She can barely communicate with him, since he doesn’t take her words at face value.
Quote 2
Horror! horror! she wanted to cry. (She had left her people; they had warned her what would happen.) (1.84)
Rezia struggles with Septimus’ madness. She misses her sisters and Italy, and feels that she doesn’t deserve to suffer as much as she does. She's not only emotionally isolated, but physically isolates as well.
Quote 3
She was exposed; she was surrounded by the enormous trees, vast clouds of an indifferent world, exposed; tortured; and why should she suffer? Why? (4.36)
Rezia has no one to turn to. Her sisters are in Milan and she feels that London is a cold and unfriendly place.