Jocasta in The Story of Oedipus
Yeah, she's the queen of Thebes, but her life is far from awesome. Everybody (including us) goes on and on about how cursed Jocasta's life is, but this lady really had it rough. Let's see, first she was forced to allow her only child to be abandoned on a mountain after having a pin stabbed into his ankles. (Whether or not she signs off on this is up for debate.) Later on, her husband is killed by highway robbers. Then she finds out that the new awesome guy she's married to and had kids with is actually the kid she abandoned and the guy who killed her first husband. After that, she hangs herself. See what we mean? This lady had it bad. How come nobody ever wrote a tragedy about her, huh?
Click here to hear all about the depiction of Jocasta in Sophocles' Oedipus the King.