The Crying of Lot 49 Isolation Quotes

How we cite our quotes: (Chapter.Paragraph)

Quote #1

The sight of sawdust, even pencil shavings, made him wince, his own kind being known to use it for hushing sick transmissions. (1.11)

How does Mucho become isolated from the world around him through his own self-loathing?

Quote #2

A salad of despair, in a gray dressing of ash, condensed exhaust, body wastes. (1.12)

What causes Mucho to view used automobiles this way? What does this view tell us about his own sense of loneliness and isolation?

Quote #3

"Think of it. […] A whole underworld of suicides who failed. All keeping in touch through that secret delivery system. What do they tell each other?" (5.75)

How is the Tristero meant to isolate the aliens, the dispossessed, the sick and the lonely? If that is what it actually does, is it such a bad thing?