If John Hughes had a vanity plate, it might read ESTREG for "Easter Egg," because he hid little secrets in Sixteen Candles in the form of license plates. Jake's car's plate says 21850, and 2/18/1950 is John Hughes's birthday. The grandparent's car's plate reads V58, which is referencing "Vacation '58," the short story John Hughes wrote that inspired one of his first movies, National Lampoon's Vacation. (Source)

When Sixteen Candles is shown on TV, one memorable line is changed to "I'd spit twice and die." To make up for the loss in expletive, a deleted scene is sometimes added. In the cafeteria line, Sam talks about how her carrots aren't doing anything for her bustline, and she panics that Jake might find out that she eats. Does this mean she doesn't even try the cake he gets her at the end? (Source)

Sam's little bratty brother has an Oscar nomination. Let's repeat: Sam's little bratty brother, who makes a joke about menstruation, has an Oscar nomination. At eight years old, Justin Henry became the youngest Oscar nominee ever for his role in Kramer vs. Kramer. Being around Meryl Streep definitely rubs off a bit. (Source)