Leela from Futurama: prettiest Cyclops ever? You decide.

Cyclops is the codename of X-Man Scott Summers, who can shoot a massive laser beam from his eyes.

Cyclopia is a rare genetic disorder in which infants are born with one eye in center of their heads.

One chapter of James Joyce's Odyssey-inspired Ulysses is titled "Cyclops." If Joyce references it, you know it's a big deal.

Project Cyclops was the name of a reality TV show in which giants designed couture—oh wait. No. It was a NASA program proposed to coordinate a ton of different radio telescopes that would search for alien radio signals. Just as cool.

Big Dan Teage, John Goodman's eye-patch-wearing character from O Brother Where Art Thou?,was inspired by Polyphemus, the Cyclops.