- Why does My Sister's Keeper have seven narrators? How would the book be different with only one narrator? Does each character sound unique? Are there any other voices you want to hear?
- Do you agree with Anna's decision to sue her parents? If you were the judge, would you have made the same decision?
- Do you agree with Sara that Anna should give her sister a kidney?
- What other ethical dilemmas are brought up during the book?
- Why does Picoult use so many epigraphs before the beginning of each section?
- What do they add to the story? How do they set the mood?
- Which character do you like the most? Who do you like the least? Why?
- What's up with the ending? Does it come out of left field (like the car that kills Anna)? Or did you think the story would end that way?
- What would you have done differently?
- Have you seen the film? Which ending did you like better? Were you surprised at any other changes? What would you have done differently?