- Why does Stein choose Enzo as his protagonist? What special and distinctive perspective might a pet offer that a family member, such as a child, or a spouse, could not?
- What is Enzo's one wish?
- Why did Enzo identify with Eve's hatred of doctors, and where might her dislike of doctors come from?
- What exactly is that demonic zebra that Enzo destroys, and why does it return later in the book? Might it represent something larger and more meaningful, and if so, what?
- Why do Maxwell and Trish want to keep Zoë? Why do they work so hard to get her away from her father?
- What do you think really happened in Italy, when Denny met the boy whose name was also Enzo?